What Is a Myeloproliferative Neoplasm (MPN)?

What Is a Myeloproliferative Neoplasm (MPN)?


Catalina Loveman: Can you tell us a little
bit about what is an MPN? Maureen Thyne: Yes, definitely. So, myeloproliferative neoplasms is the long
way of saying MPN, and of course, you can tell why we don’t usually use the full term;
MPN is much easier to say. Anyway, these MPNs is actually a family of
diseases of diagnoses, that are all kind of related to each other. In general, they’re all blood and bone marrow
problems. And in general, they all mean that the bone
marrow makes too much of something. So to break down the science of it, myelo
for bone marrow, proliferative for it makes too much, and neoplasm, which means that it
is a cancer, and that is a touchy subject. Maureen Thyne: In any case, so MPNs is this
group of these disorder, of these diagnoses, that affect different types of blood cells
being produced in the bone marrow. And some of them are sub diagnosed, things
like myelofibrosis or polycythemia vera or essential thrombocythemia. These can sometimes affect one type of blood
cell more or less than another, but in general all of these diagnoses mean that the bone
marrow is overproducing something.