Treating High Blood Pressure With a Fixed-Dose Combination Pill in Sri Lanka

Treating High Blood Pressure With a Fixed-Dose Combination Pill in Sri Lanka


High blood pressure is the leading cause of
mortality and cardiovascular disease globally, and it disproportionately affects people in low
and middle income countries where affordability and availability of medications
is a critical issue. A single pill combining fixed low-doses of several generic antihypertensives could
theoretically lower blood pressure more than usual care in these countries while
also lowering cost and improving adherence. To test this approach, researchers randomized
700 patients with mild or moderate hypertension at urban Sri Lankan hospital clinics to a once-daily triple combination pill
containing telmisartan, amlodipine, and chlorthalidone, or to usual care
consistent with local guidelines. They measured the proportion of patients who
had achieved blood pressures