#TomorrowsDiscoveries: Connecting Heart Failure and Arrhythmias—Dr. Mark Anderson

#TomorrowsDiscoveries: Connecting Heart Failure and Arrhythmias—Dr. Mark Anderson


[MUSIC] Heart disease is the major cause
of death in the developed world. When heart muscle is unable
to pump enough blood, the result is heart failure. And arrhythmias occur when
the heart’s electrical system becomes disorganized. Heart failure and arrhythmias
lead to enormous suffering, premature death, and cost. Unfortunately, we are so
far unable to prevent and adequately treat them. Surprisingly, it is not
certain why arrhythmias and heart failure occur together. Our laboratory discovered that
a particular type of protein, an enzyme called CaM kinase
II is abnormally activated in heart failure and arrhythmias. We are investigating
new ways for regulating CaM kinase II with
the goal of understanding how CaM kinase II contributes to
heart and other diseases. We hypothesize that CaM kinase
II hyperactivation is one important reason heart failure
and arrhythmias happen together. And that by better understanding
CaM kinase II, we will contribute to new and successful
therapies in cardiovascular and perhaps other diseases. [MUSIC]